No one should take more than 300 mcg per day of chromium without the supervision of a doctor. 15 Whether these problems were caused by chromium picolinate or, if so, whether other forms of chromium might have the same effects at these high amounts remains unclear. 14 A case of a muscle disease known as rhabdomyolysis appeared in a body builder who took 1200 mcg over 48 hours. 13 A case of anemia, liver dysfunction, and other problems appeared after four to five months of 1,200–2,400 mcg per day. Best easy-to-swallow supplement: PurePremium Chromium Picolinate. Best budget-friendly supplement: NOW Foods GTF Chromium. A case of kidney failure appeared after taking 600 mcg per day for six weeks. Best low dose supplement: Superior Labs Chromium Picolinate. A randomized, double-masked, placebo-controlled study of. Three single, unrelated cases of toxicity have been reported from use of chromium picolinate. Chromium picolinate supplementation in women: effects on body weight, composition, and iron status. 12 However, no published evidence supports this assertion. Another source claimed that there have been reports of mild heart rhythm abnormalities with excessive chromium ingestion. This mineral is currently being used as a food supple- ment in sports in order to promote a greater muscle mass gain and loss of body fat. 11 However, chromium supplementation was not proven to be the cause of these problems. One report of severe illness (including liver and kidney damage) occurring in a person who was taking 1,000 mcg of chromium per day has been reported. Aim: This pilot study was designed to determine whether 600 microg niacin-bound chromium ingested daily over 2 months by African-American women undergoing a modest dietary and exercise regimen influences weight loss and body composition. It seems that the effect of chromium in the reduction of blood glucose is insignificant, and results are inconsistent in relation to dyslipidemia. Another study reported the beneficial effect of chromium on weight reduction. 9 In theory, these changes could increase the risk of cancer, but so far, chromium intake has not been linked to increased incidence of cancer in humans. Two studies that evaluated the effect of chromium on body weight or body mass index reported no effect. Studies have been mixed, with some finding that chromium. 7, 8 Chromium picolinate can be altered by antioxidants or hydrogen peroxide in the body to a form that could itself create free radical damage. Chromium is often advertised as a weight-loss aid and a way to improve lean muscle and reduce body fat. One study suggested that chromium in very high concentrations in a test tube could cause chromosomal mutations in ovarian cells of hamsters. While there are a few reports of people developing medical problems while taking chromium, a cause-effect relationship was not proven. While some studies have observed reductions in. In supplemental amounts (typically 50–300 mcg per day), chromium has not been found to cause toxicity in humans. Studies examining the effects of chromium supplementation on lipid profiles have given inconsistent results.
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